The Genesis Mission is a US government program, led by the White House and run largely through the Department of Energy, to use artificial intelligence to speed up scientific research. President Trump launched it with Executive Order 14363 on November 24, 2025. The core idea is a shared platform that links the national laboratories' supercomputers and federal scientific datasets with AI models and agents, then points that platform at a list of national science and technology challenges. In July 2026, the White House announced more than $5 billion in federal commitments as more agencies joined.
Since the September 2026 terminology order, the White House describes the Genesis Mission as "a national effort to harness Super Intelligence." This guide explains what the order requires, what has been announced since, and how researchers and companies can take part.
What the Genesis Mission executive order says
Executive Order 14363, "Launching the Genesis Mission," was published in the Federal Register on November 28, 2025, at 90 FR 55035. Its purpose section compares the effort's urgency and ambition to the Manhattan Project, and says the mission "will build an integrated AI platform to harness Federal scientific datasets" to "train scientific foundation models and create AI agents to test new hypotheses, automate research workflows, and accelerate scientific breakthroughs."
The order splits responsibilities:
- The Secretary of Energy implements the mission within the Department of Energy, sets priorities and makes sure the department's resources feed into one secure platform.
- The Assistant to the President for Science and Technology provides overall leadership and coordinates other agencies through the National Science and Technology Council.
The White House announcement named the National Science Foundation, the National Institute of Standards and Technology and the National Institutes of Health among the agencies involved.
The American Science and Security Platform
The order's central piece is the American Science and Security Platform, which the Department of Energy must build and run. According to section 3, it is meant to provide:
- high-performance computing, including national laboratory supercomputers and secure cloud AI environments
- AI modeling frameworks, including AI agents that explore designs and automate workflows
- computational tools such as predictive and simulation models
- domain-specific scientific foundation models
- secure access to proprietary, federally curated and open datasets, plus synthetic data
- tools for autonomous and AI-assisted experiments and manufacturing
The order requires the platform to meet classification, supply-chain and federal cybersecurity standards, and sets strict vetting rules for outside users.
Deadlines in the order
| Days after signing | Approximate date | Task |
|---|---|---|
| 60 | January 23, 2026 | Energy Secretary lists at least 20 national science and technology challenges |
| 90 | February 22, 2026 | Identify computing, storage and networking resources, including from industry |
| 120 | March 24, 2026 | Identify initial data and model assets and a plan for adding outside datasets |
| 240 | July 22, 2026 | Review robotic labs and production facilities for AI-directed experiments |
| 270 | August 21, 2026 | Seek to show an initial operating capability on at least one challenge |
| 1 year | November 24, 2026 | First annual report to the President |
Spoken plainly: the challenge list was due within 60 days, resource and data plans within 90 and 120 days, a review of robotic labs within 240 days, a first working demonstration within 270 days, and an annual report every year starting November 2026. The approximate dates are our own count from the signing date. We have not found official confirmation of when each early deadline was met.
The order says the initial challenges should span priority areas including advanced manufacturing, biotechnology, critical materials, nuclear fission and fusion energy, quantum information science, and semiconductors and microelectronics.
What has been announced since
The biggest update came on July 22, 2026, at the Genesis Mission 2026 Summit.
- More than $5 billion in federal commitments. The White House said more than 15 federal agencies would contribute research awards, funding opportunities, datasets and facilities, using the Department of Energy's platform. It called the mission "a whole-of-government initiative."
- 278 projects selected. The Department of Energy said its first request for applications drew the largest response to a funding opportunity in its history. The 278 awards are led by 87 national laboratory teams, 168 universities, 19 companies and 4 nonprofits, and involve 342 institutions in total. The largest is a three-year, $60 million nuclear energy project. The department notes that selection is not a commitment to fund until negotiations finish.
- More than $800 million from partners. A separate Energy Department release said the Genesis Mission Consortium had secured over $800 million in partner commitments, including computing credits, access to AI models, cloud infrastructure and funding. The consortium includes all 17 national laboratories, five National Nuclear Security Administration sites and 41 industry, nonprofit and philanthropic organizations.
- A stated goal. The department describes the aim as doubling the productivity and impact of American science and engineering within a decade.
Examples of national challenges
The July White House release grouped new challenges under five themes. A few examples, in its words or close paraphrase:
- Longer, healthier lives: finding root causes of chronic disease and unlocking cures for pediatric cancer, using health cohort data and national laboratory computing.
- Infrastructure and energy: using AI and digital twins to plan and run the power grid.
- Industrial strength: an AI-driven design ecosystem to restore US leadership in microelectronics.
- Frontiers of discovery: applying AI to more than 150 petabytes of NASA space data, and building autonomous "self-driving" laboratories.
- Emerging threats: early detection and attribution of biological threats.
Strengths and open questions
Strengths the government points to (pros)
- Uses data and supercomputers the federal government already has.
- Brings many agencies onto one platform rather than separate efforts.
- Opens access to universities, companies and nonprofits through competitive awards.
Open questions (cons and risks)
- Most spending depends on appropriations; the order repeatedly says actions are "subject to available appropriations."
- Selected projects still have to finish award negotiations.
- Security, data-access and intellectual property rules for outside partners are complex, and the order asks the department to set them.
How to take part
- Researchers: watch for Department of Energy requests for applications and agency funding opportunities on the Genesis Mission site. The order also calls for fellowships, internships and apprenticeships placing participants at national laboratories.
- Companies and nonprofits: the consortium and cooperative research agreements are the main routes the order describes.
- Everyone else: AI research tools such as Elicit, Semantic Scholar and Gemini Notebook can help you follow published results. For context on AI-for-science work outside government, see labs such as Google DeepMind, and for compute trends, Epoch AI.
Who this is for
Scientists, research administrators, companies selling computing or AI services to government, and anyone tracking US AI policy. For where Genesis sits among other federal actions, see our SI timeline. For the related legislative proposals, see the National AI Policy Framework guide, and for the new "SI" vocabulary used to describe it, see what SI means, SI vs AI for businesses and agencies and our superintelligence executive order guide.
FAQ
What is the Genesis Mission?
It is a national effort, launched by Executive Order 14363 on November 24, 2025, to use AI to accelerate scientific discovery. The Department of Energy builds and runs a shared platform of supercomputers, datasets and AI models, and federal agencies use it to tackle national science challenges.
Who runs the Genesis Mission?
The Secretary of Energy implements it within the Department of Energy, and the Assistant to the President for Science and Technology leads it overall, coordinating agencies through the National Science and Technology Council.
How much funding does the Genesis Mission have?
In July 2026 the White House announced more than $5 billion in federal commitments across agencies, and the Department of Energy reported more than $800 million in partner commitments. Much of the work depends on available appropriations.
How many Genesis Mission projects have been selected?
The Department of Energy selected 278 projects involving 342 institutions in its first round, announced July 22, 2026. Selection is subject to award negotiations.
Why is the Genesis Mission called a Super Intelligence program now?
Because Executive Order 14434 told agencies to use "Super Intelligence" in place of "AI." The September 2026 fact sheet describes Genesis as a national effort to harness Super Intelligence. The program itself has not changed because of the renaming.